Apoptosis-Inducing Factor Is a Target for Ubiquitination through Interaction with XIAP
نویسندگان
چکیده
منابع مشابه
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP.
X-linked inhibitor of apoptosis (XIAP) is an inhibitor of apoptotic cell death that protects cells by caspase-dependent and independent mechanisms. In a screen for molecules that participate with XIAP in regulating cellular activities, we identified apoptosis-inducing factor (AIF) as an XIAP binding protein. Baculoviral IAP repeat 2 of XIAP is sufficient for the XIAP/AIF interaction, which is d...
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The physiological activity of Notch is a function of its ability to increase survival in many cell types. Several pathways have been shown to contribute to the survival effect of Notch, but the exact mechanism of Notch action is not completely understood. Here we identified that the regulation of cell survival by Notch intracellular domain could partly be attributed to a selective increase of X...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2008
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.01065-07